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Test Code CPAVP Copeptin proAVP, Plasma

Specimen Required

Patient Preparation: For water-deprived testing, have the patient fast and thirst for at least 8 hours (no liquids, including water, are allowed).

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic screw-top aliquot tube

Specimen Volume: 0.5 mL

Collection Information: Centrifuge and aliquot plasma. Do not submit in original tube.

Secondary ID


Useful For

The investigation of the differential diagnosis of patients with water balance disorders, including diabetes insipidus in conjunction with osmolality and hydration status


May aid in the evaluation of cardiovascular disease in conjunction with other cardiac markers.

Method Name

Immunofluorescent Assay

Reporting Name

Copeptin proAVP, P

Specimen Type

Plasma EDTA

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma EDTA Refrigerated (preferred) 7 days
  Frozen  30 days

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK
Other Original collection tube: plasma not poured off into an aliquot tube

Reference Values

Non-water deprived, non-fasting adults: <13.1 pmol/L

Water deprived, fasting adults: <15.2 pmol/L

Non-water deprived, non-fasting pediatric patients: <14.5 pmol/L


1. The reference interval for non-water deprived healthy adults is from Keller T, Tzikas S, Zeller T, et al: Copeptin improves early diagnosis of acute myocardial infarction. J Am Coll Cardiol 2010 May 11;55(19):2096-2106

2. The reference interval for fasting and water deprived adults (at least 8 hours of fasting and water deprivation) was determined from an in-house Mayo study.

3. The reference interval for non-water deprived healthy pediatric individuals is from Du JM, Sang G, Jiang CM, et al: Relationship between plasma copeptin levels and complications of community-acquired pneumonia in preschool children. Peptides 2013 Jul;45:61-65

Day(s) and Time(s) Performed

Monday through Friday; 8 a.m.-4 p.m.

Saturday; 8 a.m. -5 p.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
CPAVP Copeptin proAVP, P In Process


Result ID Test Result Name Result LOINC Value
CPAVP Copeptin proAVP, P 78987-5

NY State Approved